The effect of computerized cognitive rehabilitation on working & prospective memory function in Multiple Sclerosis patients.

Authors
Hossein zare
aliakbar sharifi
Payame Noor Universtiy
Abstract
Multiple sclerosis (MS) is a demyelinating disease of the CNS that due to cognitive impairment, can reduce the quality of life in these patients. The aim of this study is to evaluate effect of computerized cognitive rehabilitation on prospective & working memory function in Multiple Sclerosis patients. 46 MS patients aged 20–40 who have the inclusion criteria, were randomly assigned to experimental and waiting-list control groups. Experimental group trained for 12 session with a Memory rehabilitation software and waiting-list control group did not receive any intervention and training of this group was postponed after conducting research. Daneman and Carpenter's capacity working memory and Retrospective-Prospective Memory Scale was applied at pretest, posttest, and follow-up. The results of repeated measures ANOVA showed a significant difference between the means of working memory in experimental and waiting-list control groups. Also, the results of the present study indicate that a significant difference between the means of prospective memory in experimental and waiting-list control groups. Moreover, the post-test and follow-up scores in the experimental group was not statistically different. So Computerized cognitive rehabilitation have significant effect on prospective and working memory performance in patients with Multiple sclerosis and it can be used as an effective and helpful method to improve memory performance of these patients.
Keywords
working memory
prospective memory
cognitive rehabilitation
Multiple Sclerosis
Asadzadeh, H. (2008) Investigating the Relationship between Working Memory Capacity and Academic Performance among Students in the Third Grade of Junior High School in Tehran. Quarterly Journal of Education, 97, 53-69. [Persian].
Björkdahl, A., Akerlund, E., Svensson, S., & Esbjörnsson, E. (2013). A randomized study of computerized working memory training and effects on functioning in everyday life for patients with brain injury. Brain Injury, 27(13–14), 1658–65.
Brenner, P., & Piehl, F. (2016). Fatigue and depression in multiple sclerosis: pharmacological and non-pharmacological interventions. Acta Neurologica Scandinavica, 134 Suppl, 47–54.
Cerasa, A., Gioia, M. C., Valentino, P., Nisticò, R., Chiriaco, C., Pirritano, D., Quattrone, A. (2013). Computer-assisted cognitive rehabilitation of attention deficits for multiple sclerosis: a randomized trial with FMRI correlates. Neurorehabilitation and Neural Repair, 27, 284–295.
Chiaravalloti, N. D., Moore, N. B., Nikelshpur, O. M., & DeLuca, J. (2013). An RCT to treat learning impairment in multiple sclerosis: The MEMREHAB trial. Neurology, 81(24), 2066–2072.
Dagenais, E., Rouleau, I., Tremblay, A., Demers, M., Roger, É, Jobin, C., & Duquette, P. (2016). Role of executive functions in prospective memory in multiple sclerosis: Impact of the strength of cue–action association. Journal of Clinical and Experimental Neuropsychology, 38(1), 127–140.
Daneman, M., & Carpenter, P. A. (1980). Individual differences in working memory and reading. Journal of Verbal Learning and Verbal Behavior, 19(4), 450–466.
Faul, F., Erdfelder, E., Lang, A.-G., & Buchner, A. (2007). G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods, 39(2), 175–191.
Filippi, M., & Rocca, M. A. (2013). Let’s rehabilitate cognitive rehabilitation in multiple sclerosis. Neurology, 81(24), 2060–2061.
Freeman, J. A. (2001). Improving mobility and functional independence in persons with multiple sclerosis. Journal of Neurology, 248(4), 255–259.
Hanssen, K. T., Saltytė Benth, J., Beiske, A. G., Landrø, N. I., & Hessen, E. (2015). Goal attainment in cognitive rehabilitation in MS patients. Neuropsychological Rehabilitation, 25(1), 137–54.
Hubacher, M., DeLuca, J., Weber, P., Steinlin, M., Kappos, L., Opwis, K., & Penner, I.-K. (2015). Cognitive rehabilitation of working memory in juvenile multiple sclerosis–effects on cognitive functioning, functional MRI and network related connectivity. Restorative Neurology and Neuroscience, 33(5), 713–725.
Judica, E., Martinelli, F., Martinelli Boneschi, F., Ungaro, D., Comola, M., Gatti, R., Rossi, P. (2011). Impact of fatigue on the efficacy of rehabilitation in multiple sclerosis. J Neurol, 258(5), 835–839.
Lanzillo, R., Chiodi, A., Carotenuto, A., Magri, V., Napolitano, A., Liuzzi, R., Brescia Morra, V. (2016). Quality of life and cognitive functions in early onset multiple sclerosis. European Journal of Paediatric Neurology, 20(1), 158–63.
Luria, A. R. (1963). Restoration of function after brain injury. New York: Macmillan.
Mojtaba Zadeh, M. (2006). Investigate the relationship between working memory, anxiety, academic achievement among students in secondary high schools in Zanjan. M.A thesis, Faculty of Psychology, University of Allameh Tabatabai. [Persian].
Sharifi, A. A. (2015). Building a computerized cognitive rehabilitation program and its effects on improving memory function of Traumatic Brain Injury patients. PhD thesis, Faculty of Psychology, payame noor University. [Persian].
Sharifi, A. A., Zare, H., & Hatami, J. (2016). The impact of computerized cognitive rehabilitation on working memory performance in patients with traumatic brain injury. Advances in Cognitive Sciences, 17, 71-78. [Persian].
Skerrett, T. N., & Moss-Morris, R. (2006). Fatigue and social impairment in multiple sclerosis: The role of patients’ cognitive and behavioral responses to their symptoms. Journal of Psychosomatic Research, 61(5), 587–593.
Sohlberg, M. M., & Mateer, C. A. (2001). Cognitive Rehabilitation: An Integrative Neuropsychological Approach. The Guilford Press.
Solari, A., Motta, A., Mendozzi, L., Pucci, E., Forni, M., Mancardi, G., & Pozzilli, C. (2004). Computer-aided retraining of memory and attention in people with multiple sclerosis: a randomized, double-blind controlled trial. Journal of the Neurological Sciences, 222(1–2), 99–104.
Stuifbergen, A. K., Becker, H., Perez, F., Morison, J., Kullberg, V., & Todd, A. (2012). A randomized controlled trial of a cognitive rehabilitation intervention for persons with multiple sclerosis. Clin Rehabil, 26(10), 882–93.
Winkelmann, A., Engel, C., Apel, A., & Zettl, U. K. (2007). Cognitive impairment in multiple sclerosis. Journal of Neurology, 254, 35-42.
Zare, H., Sharifi, A. A., & Hatami, J. (2015). The impact of computerized cognitive rehabilitation on prospective memory in patients with traumatic brain injury. Journal of Applied Psychology, 9, 1(33), 63-77. [Persian].