Predict of Obsessive Compulsive Based on Cognitive variables (Working Memory, Inhibition, Shifting, Updating and Short Term Memory)

Abstract
working memory is the comprehensive cognitive system that embedded attentional and memorical mechanisms and therefore can be used in systematic research of cognitive problems. The aim of this study was to investigate the predictive role of working memory capacity and executive functions (shifting, inhibition and updating) for Obsessive Compulsive Disorder. We selected 164 student (90 male and 74 female) from university of Tehran with random sampling method and they completed Maudsley Obsessional – Compulsive Inventory (Hodgson & Rachman, 1977), the Digit Backward Span Task (workingmemory capacity), Forward Span task (Short Term Memory), Stroop (inhibition, Spreen & Strauss, 1998), Set- Switching Task (shifting, Rogers & Monsell, 1995) and Keep Track Task (updating, Martinez, et al., 2011). Data analyzing used regression showed working memory and executive function totally predict considerable amount (67 percent) of obsessive compulsive predisposition. Therefore it can be concluding, obsessive people have crucial weakness in storage, monitoring and executive cognitive function (in general attention control) and we can use training in these functions as treatment strategies.
Keywords

References
Abramovitch,A.,Abramowitz,J.S.,Mittelman,A.,(2013).Theneuropsychologyof adult obsessive compulsive disorder: a meta- analysis. Clinical Psychology Review. 33,1163–1171.
Abramovitch,A.,Shaham,N.,Levin,L.,Bar-Hen,M.,&Schweiger,A.(2015). Response inhibition in a subclinical obsessive-compulsive sample. Journal of Behavior Therapy and Experimental Psychiatry,46(0),66–71.http://dx.doi.org/ 10.1016/j.jbtep.2014.09.001.
Abramovitch, A., Dar, R., Hermesh, H., & Schweiger, A. (2012). Comparative neuropsychology of adult obsessive-compulsive disorder and attention deficit/hyperactivity disorder: implications for a novel executive overload model of OCD. Journal of Neuropsychology, 6(2), 161e191. http://dx.doi.org/10.1111/j.1748- 6653.2011.02021.x.
Alloway, T. P., Gathercole, S. E.,Willis, C., & Adams, A. M. (2004). A structural analysis of working memory and related cognitive skills in young children. Journal of Experimental Child Psychology, 87, 85−106.
American Psychiatric Association. (2015). Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Translated by Rezaei, F., et al. Arjmand. Tehran. Iran. (Persian).
Aminzadeh, A., & Hassanabadi, H. R. (2010). Cognitive Deficits Underlying Math Disability. Developmental Psychology: Iranian Psychologists. 6 (23). 187-200. (Persian).
Anderson KE, Savage CR. (2004). Cognitive and neurobiological findings in obsessive-compulsive disorder. Psychiatr Clin North Am.27:37-47.
Andouz, Z., Sahebi, A., & Tabatabaei, S. M., (2005). Comparing Efficacy and Effectiveness of ERP and DIRT Methods in Treatment of Compulsive Washing. Iranian Journal of Psychiatry Clinical Psychology. 11 (2). 139-149. (Persian).
Baddeley, A., (2010). Working memory. Current Biology, 20(4), 136-141.
Bull, R., & Espy, K. A. (2006). Working memory, executive functioning, and children’s mathematics. In S. Pickering (Ed)., Working memory and education. Elsevier Press.
Bucci P, Mucci A, Volpe U, Merlotti E, Galderisi S, Maj M. (2004). Executive hypercontrol in obsessive-compulsive disorder: electrophysiological and neuropsychological indices. Clin. Neurophysiol. 115: 1340–1348.
Chamberlain SR, Blackwell AD, Fineberg NA, Robbins TW, Sahakian BJ (2005). The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neuroscience and Biobehavioural Reviews 29, 399–419.
Chamberlain, S. R., Muller, U., Blackwell, A. D., Clark, L., Robbins, T. W., & Sahakian, B. J. (2006). Neurochemical modulation of response inhibition and probabilistic learning in humans. Science, 311(5762), 861–863.
Cox C.(1997). Neuropsychological abnormalities in obsessive compulsive disorder and their assessments. Int Rev Psychiatry; 9:45–59
Engle de Abreu, P. M. J., Conway, A. R. A., Gathercole, S. E.(2010). Working memory and fluid intelligence in young children. Intelligence. 38, 552-561.
Gathercole, S. E., Pickering, S. J., Ambridge, B., & Wearing, H. (2004). The structure of working memory from 4 to 15 years of age. Developmental Psychology, 40(2), 177−190.
Hekmati, I., Hashemi, T., & Pirzadeh, J. (2012). Comparison of executive functions in subclinical obsessive compulsive disorder without depressive symptoms with healthy controls. Journal of Behavioral Sciences. 6 (1), 39-47. (Persian).
Hughes, M., Linck, J. A., Bowles, A. R., Koeth, J. T., Bunting, M. F. (2014). Alternative to switch cost scoring in the task switching paradigm: their reliability and increased validity. Behavior Research Methods. 46 (3): 702-721.
Harkin, B., & Kessler, K. (2011). The role of working memory in compulsive checking and OCD: a systematic classification of 58 experimental findings. Clinical Psychology Review. 31(6):1004-21
Head, D., Bolton, D., & Hymas, N. (1989). Deficit in cognitive shifting ability with obsessive–compulsive disorder. Biological Psychiatry, 25, 929–937
Henseler, I., Gruber, O., Kraft, S., Krich, C., Reith, W., & Falkai, P. (2008). Compensatory hyperactivations as markers of latent working memory dysfunctions in patients with obsessive compulsive disorder: an FMRI study. J Psychiatry Neurosci, 33 (3), 209-215.
Irak M, Flament MF. (2007). Neuropsychological profile of childhood-onset obsessive-compulsive disorder. Turk Psikiyatri Derg;18:293–301.
Kormi-Nouri, R., & Moradi, A. (2009). Reading and dyslexia test. Jahad Daneshgahi. Tehran. Iran. (Persian).
Kuelz AK, Hohagen F, Voderholzer U. (2004). Neuropsychological performance in obsessive-compulsive disorder: a critical review. Biol Psychol 2004;65:185-236.
Martinez, K., Burgaleta, M., Roman, F. J., Escorial, S., Shih, P. C., Quiroga, M. A., & Colom, R. (2011). Can fluid intelligence be reduced to simple short term storage? Intelligence, 39, 473-480.
Miyake, A., Friedman, N. P., Emerson, M. J., Witzki, A. H., Howerter, A., & Wager, T. D. (2000). The unity and diversity of EFs and their contributions to complex “frontal lobe” tasks: A latent variable analysis. Cognitive Psychology, 41,49–100.
Muller, J., & Roberts, J. (2005). Memory and attention in obsessive compulsive disorder: a review. Anxiety Disorders. 19: 1-28.
Rogers R.D., Monsell S. (1995). The cost of a predictable switch between simple cognitive tasks. Journal of Experimental Psychology: General, 124, 207–231.
Rubenstein, C. S., Peynirdoglu, Z. F., Chambless, D. L., & Pigott, T. A. (1993). Memory in subclinical obsessive–compulsive checkers. Behavior Research and Therapy, 31, 759–765.
Sadeghi, A., Rabiee, M., & Abedi, M. R. (2011). Validation and reliability of the Wechsler intelligence scale for children. Developmental Psychology: Iranian Psychologists. 7 (28). 377-386. (Persian).
Sanz, M., Molina, V., Calcedo, A., Martin-Loeches, M., & Rubia, F. J. (2001). The Wisconsin Card Sorting Test and the assessment of frontal function in obsessive-compulsive patients: An event-related potential study. Cognitive Neuropsychiatry, 6, 109-129. 10.1080/13546800042000089.
Savage, C.R., (1998). Neuropsychology of OCD: research findings and treatment implications. In: Jenike, M.A., Baer, L., Minichinello, W.E. (Eds.), Obsessive-Compulsive Disorders: Practical Management, (Third ed.) Mosby, St. Louis, MO, pp. 254 – 275.
Savage, C. R., Deckersbach, T., Wilhelm, S., Rauch, S. L., Baer, L., Reid, T., et al. (2000). Strategic processing and episodic memory impairment in obsessive compulsive disorder. Neuropsychology, 14(1), 141–151.
Saxena S, Brody AL, Ho ML, Alborzian S, Ho MK, Maidment KM, et al. (2001). Cerebral metabolism in major depression and obsessive-compulsive disorder occurring separately and concurrently. Biol Psychiatry. 50: 159-70.
Sawamura K, Nakashima Y, Inoue M, Kurita H.(2005). Short-term verbal memory deficits in patients with obsessive-compulsive disorder. Psychiatry Clin Neurosci. 59:527-32.
Sharma, S., Kumar, V., trivedi, J., Dalal, P. K., kumar, P., Sudarshanan, S., & Chaudhary, S. (2012). Working memory deficits in obsessive compulsive disorder. Delhi Psychiatry Journal. 15 (2). 338-341.
Snyder, H., Ksiser, R. H., Warren, S. L., & Heller, W. (2015). Obsessive compulsive disorder is associated with broad impairments in executive function: a meta analysis. Clin Psychol Sci, 3 (2): 301-330.
Spreen, O., & Strauss, E. (1998). A compendium of neuropsychological tests: Adminsitration, norms, and commentary (2nd ed.). NY: Oxford University Press.
Tolin, D. F., Abramowitz, J. S & Brigidi, B. D. (2001). Memory and memory confidence in onsessive compulsive disorder. Behaviour research and Therapy. 39: 913-927
Tukel, R., Gurvit, H., Aslantas, B., Oflaz, S., Ertekin, E. Baran, B., and et al. (2012). Neuropsychological function in obsessive compulsive disorder. Comprehensive Psychiatry. 53. 167-175.
Watkins LH, Sahakian BJ, Robertson MM, Veale DM, Rogers RD, Pickard KM et al (2005). Executive function in Tourette’s syndrome and obsessive-compulsive disorder. Psychol Med 35: 571–582