بررسی اثربخشی تحریک دو طرفه مکرر مغناطیسی فراجمجمه ای بر روی عملکرد شناختی بیماران مبتلا به افسردگی دو قطبی

نویسندگان
رضا کاظمی 1
عزت الله قدم پور 1
رضا رستمی 2
ساناز خمامی 3
مهدی رضایی 1
1 دانشگاه لرستان
2 دانشگاه تهران
3 دانشگاه شهید چمران اهواز
چکیده
هدف از پژوهش حاضر بررسی اثربخشی تحریک دو طرفه مکرر مغناطیسی فراجمجمه ای (rTMS) بر روی عملکرد شناختی بیماران مبتلا به افسردگی دو قطبی بود. در یک طرح آزمایشی یک سو کور 20 بیمار مبتلا به افسردگی دو قطبی مراجعه کننده به مرکز علوم اعصاب آتیه از فروردین تا شهریور 1394 با روش نمونه گیری تصادفی انتخاب شدند. rTMS دوطرفه را در طی 10 جلسه بر روی قشر خلفی جانبی پیش پیشانی چپ (فرکانس Hz10) و قشر خلفی جانبی پیش پیشانی راست (Hz1) دریافت کردند. آزمودنی ها از طریق آزمون سیّالی کلامی، آزمون یادگیری شنوایی- کلامی ری، آزمون استروپ، آزمون دسته بندی کارتهای ویسکانسین، مقیاس افسردگی بک در قبل و در بعد از درمان ارزیابی شدند و در نهایت داده ها به کمک روش آماری t همبسته تحلیل شدند.rTMS دوطرفه باعث تغییرات معناداری در عملکرد اجرایی و حافظه کلامی و علائم افسردگی شد. هیچ تغییر معناداری در توجه انتخابی و سیالی کلامی مشاهده نگردید (05/0<p). rTMS دو طرفه باعث بهبودی معناداری در علائم شناختی و کاهش علائم افسردگی بیماران مبتلا به افسردگی دو قطبی می گردد.
کلیدواژه‌ها
اختلال دو قطبی
تحریک مکرر مغناطیسی فراجمجمه ای
عملکرد شناختی

عنوان مقاله English

The Effectiveness of Bilateral rTMS on cognitive function in Patients with Bipolar Depression

نویسندگان English

Reza Kazemi 1
Ezatollah Ghadampur 1
Reza Rsotami 2
Sanaz Khomami 3
mehdi Rezaee 1
1 , Lorestan University
2 University of Tehran
3 Shahid Chamran University of Ahvaz
چکیده English

The aim of the present study was to investigate of the efficacy of bilateral repetitive transcranial magnetic stimulation on cognitive function in patients with bipolar depression. In a single-blind experimental trial, 20 patients with bipolar depression who had been referred to Atieh clinical neuroscience center were selected randomly from April to September 2015. The patients received bilateral repetitive transcranial magnetic stimulation on left dorsolateral prefrontal cortex (10Hz) and right dorsolateral prefrontal (1Hz) during 10 sessions. The subjects were evaluated through verbal fluency test, Rey Auditory-Verbal learning Test, Stroop Test, Wisconsin Card sorting Test, Beck depression inventory before and after the treatment. The data were analyzed by paired t test. Bilateral rTMS was caused to significant changes in executive function and verbal memory and depressive symptoms. No significant changes were observed in selective attention and verbal fluency (p>0/05). Bilateral repetitive transcranial magnetic stimulation is caused to significant improvement in cognitive symptoms and reduces the symptoms of depression in patients with bipolar depression.

کلیدواژه‌ها English

bipolar disorder
repetitive transcranial magnetic stimulation
cognitive function
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