مقایسۀ توان، فرکانس پیک آلفا و ناقرینگی آلفای پیشانی در بیماران مبتلا به سندرم رودۀ تحریک‌پذیر و افراد سالم

نویسندگان
سپیده دهقانی 1
رضا رستمی 1
محمد علی بشارت 1
رضا زمردی 2
همایون واحدی 3
1 دانشگاه تهران
2 مرکز تحقیقات اعتیاد و سلامت روان
3 دانشگاه علوم پرشکی تهران
چکیده
سندرم رودۀ تحریک­‌پذیر (IBS) یک اختلال مزمن کنشی گوارشی است که با علایمی مانند درد یا ناراحتی شکمی و تغییر در عادات روده‌­ای همراه است. هدف از پژوهش حاضر مقایسۀ مشخصه‌­های نوسانات مغزی، به طور خاص‌ریال در باند فرکانسی آلفا، با استفاده از الکتروانسفالوگرافی در حالت استراحت بین افراد مبتلا به IBS و افراد سالم بود. بدین منظور 11 نفر (7 زن و 4 مرد) بیمار مبتلا به IBS و 11 نفر (7 زن و 4 مرد) سالم که از نظر سن و جنسیت با گروه بیمار همتا­سازی شده بودند، انتخاب و نوسانات مغزی آن‌ها با استفاده از EEG 64 کاناله در حالت استراحت و با چشمان بسته ثبت شد. توان آلفا، فرکانس پیک آلفا و ناقرینگی آلفای پیشانی با استفاده از روش تبدیل فوریه سریع و آزمون t مستقل محاسبه و مورد تجزیه و تحلیل قرار گرفت. نتایج به دست آمده نشان داد که میانگین توان آلفا در گروه بیمار بیشتر از گروه سالم و فرکانس پیک آلفا و ناقرینگی آلفای پیشانی در گروه بیمار کمتر از گروه سالم بود. با توجه به یافته­‌های پژوهش نتیجه­‌گیری می­‌شود که عملکرد قشری و امواج مغزی تولید شده در باند فرکانسی آلفا بین افراد مبتلا به IBS و افراد سالم متفاوت است و یافته‌­ها می­تواند شناساسایی نشانگر­های زیستی و پیش­بینی‌­کنندۀ اثرات درمانی در بیماران مبتلا به IBS مورد استفاده قرار گیرد.
کلیدواژه‌ها
سندرم روده تحریک‌پذیر
توان آلفا
فرکانس پیک آلفا
ناقرینگی آلفای پیشانی
طب شخصی شده

عنوان مقاله English

The Comparison of Alpha Power, Peak Alpha Frequency and Frontal Alpha Asymmetry between Patients with Irritable Bowel Syndrome and Healthy People

نویسندگان English

sepideh dehghani 1
Reza Rostami 1
Mohammad Ali Besharat 1
Reza Zomorrodi 2
Homayoun Vahedi 3
1 University of Tehran
2 , University of Toronto
3 Tehran University of Medical Sciences
چکیده English

Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder that is characterized by abdominal pain, discomfort and change in the intestinal habits. The aim of this study was the comparison of brain oscillations features between patients with IBS and healthy control, speciallity in alpha frequency band by using rest-electroencephalography (EEG). 11 IBS patients (7 females and 4 male) and 11 healthy (7 females and 4 male), gender and age-matched, were selected and brain oscillations were recorded by a 64-channel EEG at rest in eye-closed condition. Alpha power, peak alpha frequency and frontal alpha asymmetry were calculated and analyzed by fast Fourier transform and independent t test. The results showed that in IBS group, the average of alpha was higher, the peak alpha frequency and frontal alpha asymmetry are lower than healthy control. Our findings indicated that difference between healthy control and IBS group in their cortical functions and generated brain wave oscillation, specifically in alpha frequency bands. Theses results may serve as a biomarker and prognostic tools for IBS treatments.

کلیدواژه‌ها English

Irritable bowel syndrome
alpha power
peak alpha frequency
frontal alpha asymmetry
personalized medicine
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